ZBTB22

Across TCGA patient cohorts, ZBTB22 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB22-associated genes across cancer lineages are Notch1, Shc_pY317, and 14-3-3_beta. Each is linked with ZBTB22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB22-to-partner and partner-to-ZBTB22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZBTB22-low versus ZBTB22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB22→partner) and Y-score (partner→ZBTB22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.217	+2.000	<.001	.010	3	2
UCEC	Shc_pY317 →	-0.172	-2.000	.003	.010	3	2
UCEC	14-3-3_beta →	-0.085	-2.432	.031	.018	3	1
UCEC	EGFR_pY1068 →	-0.291	-2.700	.003	.006	3	1
UCEC	A-Raf_pS299 →	-0.149	-2.584	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-1.571	.003	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Notch1 by ZBTB22 expression — UCEC

Explore this box plot interactively →