ZBTB22

Across TCGA cell cohorts, ZBTB22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,525 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZBTB22-associated GO terms across cancer lineages are Regulation of macroautophagy, Negative regulation of autophagy, and Negative regulation of DNA-templated transcription initiation. Each is linked with ZBTB22 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZBTB22-to-partner and partner-to-ZBTB22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by ZBTB22-low versus ZBTB22-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB22→partner) and Y-score (partner→ZBTB22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of macroautophagy →	+0.076	+0.954	<.001	<.001	2	16
STOMACH	Negative regulation of autophagy →	+0.082	+0.631	<.001	<.001	3	14
STOMACH	Negative regulation of DNA-templated transcription initiation →	+0.130	+0.670	.003	.007	3	14
STOMACH	Negative regulation of transcription initiation by RNA polymerase II →	+0.130	+0.670	.003	.007	3	14
UPPER_AERODIGESTIVE_TRACT	Post-Golgi vesicle-mediated transport →	+0.065	+1.084	.003	<.001	3	14
STOMACH	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.152	+0.921	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,525 associations by consensus.

Regulation of macroautophagy by ZBTB22 expression — STOMACH

Explore this box plot interactively →