ZBTB20-AS5

Across TCGA pan-cancer cohorts, ZBTB20-AS5 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated ZBTB20-AS5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZBTB20-AS5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB20-AS5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LAML show a favorable association.

HNSC, THCA, and KIRC are the cancer types where ZBTB20-AS5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.555	0.746	.003	52	view →
THCA	OS	Tertile	II,III,IV	0.703	0.964	.005	36	view →
KIRC	DFS	Median	II,III,IV	0.646	0.769	.006	35	view →
SKCM	DFS	Tertile	All	0.303	0.164	<.001	33	view →
LAML	DFS	Tertile	All	0.539	0.244	.004	26	view →
CHOL	DFS	Median	All	0.629	0.132	.006	22	view →
STAD	DFS	Tertile	III,IV	0.747	0.466	.016	12	view →
TGCT	DFS	Tertile	All	0.923	0.755	.034	12	view →
LUSC	DFS	Quartile	III,IV	0.154	0.739	.020	6	view →
READ	OS	Tertile	All	0.833	0.933	.013	3	view →
LUAD	OS	Median	All	0.481	0.280	.030	3	view →
PRAD	OS	Median	All	0.995	0.806	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

ZBTB20-AS5–HNSC (OS)

Open the HNSC breakdown →