ZBTB20-AS4

Across TCGA pan-cancer cohorts, ZBTB20-AS4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZBTB20-AS4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZBTB20-AS4 RNA is repressed in tumor relative to normal tissue. In most cancer types ZBTB20-AS4 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and KIRC are the cancer types where ZBTB20-AS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB20-AS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.808	<.001	9	view →
KIRP	Male	All	−0.373	<.001	9	view →
KIRC	Male	II,III,IV	−0.353	<.001	9	view →
LUSC	All	II,III,IV	−0.386	<.001	8	view →
UCEC	All	All	−0.343	<.001	6	view →
HNSC	Male	All	−0.127	.013	4	view →
LUAD	All	III,IV	−0.314	.004	3	view →
COAD	All	II,III,IV	−0.137	.011	3	view →
STAD	Male	IV	−0.664	.045	1	view →
KICH	All	III,IV	−0.401	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZBTB20-AS4–THCA

Open the THCA breakdown →