Across TCGA pan-cancer cohorts, ZBTB14 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZBTB14 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher ZBTB14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, COAD, and UCEC are the cancer types where ZBTB14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.203	0.678	<.001	33	view →
COAD	OS	Median	III,IV	0.056	0.783	<.001	24	view →
UCEC	OS	Median	All	1.000	0.640	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZBTB14 tumor-vs-normal RNA expression · all ZBTB14 data types