Across TCGA pan-cancer cohorts, ZBTB14 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZBTB14’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where ZBTB14 RNA is repressed in tumor relative to normal tissue. In most cancer types ZBTB14 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, KIRC, and LIHC are the cancer types where ZBTB14 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB14 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.