ZBTB11

Across TCGA patient cohorts, ZBTB11 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB11-associated genes across cancer lineages are EGFR_pY1068, ERK2, and GAPDH. Each is linked with ZBTB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB11-to-partner and partner-to-ZBTB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZBTB11-low versus ZBTB11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB11→partner) and Y-score (partner→ZBTB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.227	-1.662	.002	.010	3	2
UCEC	ERK2 →	+0.152	+1.432	.007	.005	3	2
UCEC	GAPDH →	+0.397	+2.321	.012	.005	3	2
UCEC	GATA6 →	-0.137	-2.792	.003	.002	3	2
UCEC	p53 →	-0.262	-1.584	.021	.017	3	2
UCEC	p62 Lck ligand →	+0.339	+1.857	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EGFR_pY1068 by ZBTB11 expression — UCEC

Explore this box plot interactively →