ZBTB11

Across TCGA pan-cancer cohorts, ZBTB11 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZBTB11’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZBTB11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB11 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where ZBTB11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.927	<.001	11	view →
LIHC	All	II,III,IV	+0.688	<.001	9	view →
COAD	Male	All	+0.523	<.001	6	view →
BLCA	All	III,IV	+0.461	.006	6	view →
BRCA	All	II,III,IV	+0.323	<.001	6	view →
CHOL	Male	All	+1.301	<.001	5	view →
KICH	All	All	−0.792	<.001	5	view →
THCA	All	All	−0.290	.002	5	view →
LUSC	Male	II,III,IV	+0.583	<.001	4	view →
STAD	All	II,III,IV	+0.559	.006	3	view →
KIRC	All	All	+0.207	.007	3	view →
READ	All	III,IV	+0.749	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZBTB11–HNSC

Open the HNSC breakdown →