ZBTB1

Across TCGA cell cohorts, ZBTB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,191 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZBTB1-associated GO terms across cancer lineages are Positive regulation of lymphoid progenitor cell differentiation, Positive regulation of hematopoietic progenitor cell differentiation, and Vesicle tethering. Each is linked with ZBTB1 in more than 19 cancer types. Because this analysis shows association rather than direction, both ZBTB1-to-partner and partner-to-ZBTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of lymphoid progenitor cell differentiation grouped by ZBTB1-low versus ZBTB1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB1→partner) and Y-score (partner→ZBTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of lymphoid progenitor cell differentiation →	+0.167	+0.957	<.001	<.001	3	20
BLOOD_Leukemia	Positive regulation of hematopoietic progenitor cell differentiation →	+0.207	+1.034	<.001	<.001	3	17
LUNG_SCLC	Vesicle tethering →	+0.092	+0.950	<.001	<.001	3	15
LUNG_SCLC	Protein sumoylation →	+0.104	+0.798	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.080	+1.037	<.001	.006	3	14
STOMACH	Regulation of hematopoietic progenitor cell differentiation →	+0.103	+0.877	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

Positive regulation of lymphoid progenitor cell differentiation by ZBTB1 expression — LUNG_SCLC

Explore this box plot interactively →