ZBP1

Across TCGA pan-cancer cohorts, ZBP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZBP1 data layer compared with 30 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZBP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZBP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where ZBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	0.835	0.222	.024	12	view →
HNSC	OS	Tertile	All	0.799	0.619	.024	6	view →
LUAD	DFS	Tertile	II,III,IV	0.746	0.387	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZBP1–PDAC (OS)

Open the PDAC breakdown →