ZBP1

Across TCGA cell cohorts, ZBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,988 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBP1-associated GO terms across cancer lineages are Regulation of viral life cycle, MDA-5 signaling pathway, and Negative regulation of viral genome replication. Each is linked with ZBP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZBP1-to-partner and partner-to-ZBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of viral life cycle grouped by ZBP1-low versus ZBP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBP1→partner) and Y-score (partner→ZBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of viral life cycle →	+0.113	+0.950	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.332	+1.081	<.001	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.227	+1.148	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of innate immune response →	+0.053	+0.652	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.079	+0.907	<.001	.003	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.186	+1.133	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,988 associations by consensus.

Regulation of viral life cycle by ZBP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →