ZBP1

Across TCGA cell cohorts, ZBP1 mutation is significantly associated with the mutation status of many other genes, with 2,366 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBP1-associated genes across cancer lineages are PDE3B, PRR5, and SYT16. Each is linked with ZBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZBP1-to-partner and partner-to-ZBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE3B grouped by ZBP1-low versus ZBP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBP1→partner) and Y-score (partner→ZBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDE3B →	+3.651	+4.777	.002	.002	1	4
LUNG_SCLC	PRR5 →	+5.066	+4.502	.007	.007	1	4
CNS	SYT16 →	+5.347	+4.199	<.001	<.001	1	4
BLOOD_Leukemia	CATSPERD →	+3.478	+4.347	<.001	<.001	1	4
LUNG_NSCLC_LUAD	ZNF347 →	+4.772	+5.339	.004	.004	1	4
LUNG_SCLC	ERGIC3 →	+5.066	+4.502	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,366 associations by consensus.

PDE3B by ZBP1 expression — LUNG_SCLC

Explore this box plot interactively →