ZBED6

Across TCGA patient cohorts, ZBED6 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBED6-associated genes across cancer lineages are RNA5SP305, RN7SKP204, and RNU6-841P. Each is linked with ZBED6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBED6-to-partner and partner-to-ZBED6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP305 grouped by ZBED6-low versus ZBED6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBED6→partner) and Y-score (partner→ZBED6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP305 →	+0.841	+5.081	<.001	.008	3	1
UCEC	RN7SKP204 →	+0.922	+4.982	<.001	.009	3	1
UCEC	RNU6-841P →	+0.911	+5.694	<.001	.003	3	1
UCEC	RNA5SP86 →	+1.640	+5.299	<.001	.006	3	1
UCEC	RNU6-918P →	+1.510	+5.420	<.001	.005	3	1
UCEC	VN1R37P →	+0.373	+6.226	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

RNA5SP305 by ZBED6 expression — UCEC

Explore this box plot interactively →