ZBBX

Across TCGA patient cohorts, ZBBX mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBBX-associated genes across cancer lineages are ACVRL1, Mre11, and PCNA. Each is linked with ZBBX in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBBX-to-partner and partner-to-ZBBX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by ZBBX-low versus ZBBX-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBBX→partner) and Y-score (partner→ZBBX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ACVRL1 →	-0.130	-2.879	.031	.001	3	2
LUSC	Mre11 →	-0.091	-2.981	.038	.033	3	2
UCEC	PCNA →	+0.269	+1.999	<.001	<.001	3	2
LUSC	Bcl-2 →	-0.391	-3.445	.005	.005	3	2
UCEC	eIF4E →	+0.141	+2.392	.026	<.001	3	2
SKCM	p90 RSK →	+0.195	+1.392	.002	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ACVRL1 by ZBBX expression — LUSC

Explore this box plot interactively →