ZBBX

Across TCGA pan-cancer cohorts, ZBBX RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZBBX data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ZBBX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZBBX expression acts as an unfavorable survival marker, although some lineages such as KIRP and HNSC show a favorable association.

BLCA, KICH, and COAD are the cancer types where ZBBX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.511	0.664	<.001	119	view →
KICH	OS	Quartile	All	0.762	0.969	<.001	86	view →
COAD	DFS	Tertile	All	0.625	0.815	.003	48	view →
LIHC	DFS	Tertile	II,III,IV	0.276	0.532	.004	27	view →
KIRP	DFS	Tertile	IV	0.619	0.035	.004	22	view →
HNSC	OS	Quartile	III,IV	0.759	0.601	.013	22	view →
KIRC	DFS	Tertile	All	0.761	0.849	.004	21	view →
PAAD	OS	Quartile	All	0.636	0.342	.016	13	view →
CHOL	DFS	Quartile	All	0.798	0.111	.006	12	view →
PRAD	DFS	Tertile	All	0.763	0.877	.023	12	view →
BRCA	DFS	Median	IV	0.694	0.331	.009	11	view →
CESC	OS	Median	All	0.859	0.738	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZBBX–BLCA (OS)

Open the BLCA breakdown →