ZBBX

Across TCGA cell cohorts, ZBBX mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBBX-associated genes across cancer lineages are GOT1L1, SNTG2, and TMSB4Y. Each is linked with ZBBX in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBBX-to-partner and partner-to-ZBBX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1L1 grouped by ZBBX-low versus ZBBX-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBBX→partner) and Y-score (partner→ZBBX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GOT1L1 →	+0.042	+4.437	<.001	.004	3	2
BLOOD_Leukemia	SNTG2 →	+1.192	+3.491	<.001	.009	3	2
LUNG_NSCLC_LUAD	TMSB4Y →	+0.724	+3.643	.002	.006	3	2
LUNG_NSCLC_LUAD	RTP1 →	+0.033	+3.188	.001	.004	3	2
LUNG_NSCLC_LUAD	TEX33 →	+0.015	+3.944	<.001	.006	3	2
LARGE_INTESTINE	ZNF454 →	+0.185	+2.559	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

GOT1L1 by ZBBX expression — SKIN

Explore this box plot interactively →