ZAP70

Across TCGA pan-cancer cohorts, ZAP70 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZAP70 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZAP70 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZAP70 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where ZAP70 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.794	0.438	.005	31	view →
PDAC	DFS	Median	All	0.824	0.697	.009	12	view →
LUAD	DFS	Tertile	All	0.821	0.467	<.001	11	view →
GBM	DFS	Quartile	All	0.191	0.501	.020	3	view →
HNSC	DFS	Tertile	All	0.911	0.991	.039	2	view →
UCEC	OS	Tertile	All	1.000	0.892	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZAP70–CCRCC (DFS)

Open the CCRCC breakdown →