ZAN

Across TCGA patient cohorts, ZAN RNA expression is significantly associated with the go_rna of many other GO terms, with 7,128 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ZAN-associated GO terms across cancer lineages are Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Mitochondrial gene expression, and DNA conformation change. Each is linked with ZAN in more than 18 cancer types. Because this analysis shows association rather than direction, both ZAN-to-partner and partner-to-ZAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by ZAN-low versus ZAN-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAN→partner) and Y-score (partner→ZAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.072	+0.270	<.001	<.001	3	19
STAD	Mitochondrial gene expression →	+0.083	+0.318	<.001	<.001	3	17
ESCA	DNA conformation change →	+0.080	+0.473	<.001	.001	2	17
STAD	Regulation of microtubule-based process →	+0.054	+0.308	<.001	<.001	3	16
STAD	Positive regulation of cell cycle phase transition →	+0.062	+0.268	<.001	<.001	3	16
STAD	DNA replication →	+0.074	+0.258	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,128 associations by consensus.

Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by ZAN expression — STAD

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