ZAN

Across TCGA pan-cancer cohorts, ZAN RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ZAN data layer compared with 7 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZAN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZAN expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

ACC, HNSC, and KIRC are the cancer types where ZAN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.339	0.733	<.001	95	view →
HNSC	OS	Median	All	0.450	0.278	<.001	93	view →
KIRC	OS	Median	All	0.542	0.703	<.001	76	view →
SCLC	OS	Tertile	II,III,IV	0.164	0.819	<.001	36	view →
KICH	DFS	Tertile	III,IV	0.380	0.902	.008	33	view →
ESCA	OS	Quartile	II,III,IV	0.849	0.544	.004	23	view →
CHOL	OS	Quartile	All	1.000	0.555	.004	19	view →
READ	DFS	Tertile	All	1.000	0.719	.011	12	view →
DLBC	DFS	Tertile	IV	0.195	0.923	.038	10	view →
BLCA	OS	Tertile	III,IV	0.673	0.524	.014	8	view →
SKCM	OS	Quartile	All	0.822	0.896	.012	8	view →
MESO	OS	Tertile	All	0.135	0.606	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ZAN–ACC (DFS)

Open the ACC breakdown →