ZAN

Across TCGA patient cohorts, ZAN mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZAN-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and eIF4E. Each is linked with ZAN in more than 4 cancer types. Because this analysis shows association rather than direction, both ZAN-to-partner and partner-to-ZAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZAN-low versus ZAN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZAN→partner) and Y-score (partner→ZAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.364	+2.321	.032	.030	3	5
COAD	Caspase-7-cleavedD198 →	+0.931	+2.815	.002	.001	3	5
UCEC	eIF4E →	+0.167	+2.598	<.001	<.001	3	4
COAD	C-Raf →	+0.194	+3.915	<.001	<.001	3	4
BLCA	PKC-b-II_pS660 →	-0.268	-2.584	.012	.009	3	4
UCEC	Cyclin-B1 →	+0.505	+1.353	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

ASNS by ZAN expression — STAD

Explore this box plot interactively →