Across TCGA patient cohorts, ZACN mutation is significantly associated with the RNA expression of many other genes, with 869 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZACN-associated genes across cancer lineages are RNU4-58P, IGBP1P5, and ATP5PBP4. Each is linked with ZACN in more than 2 cancer types. Because this analysis shows association rather than direction, both ZACN-to-partner and partner-to-ZACN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZACN→partner) and Y-score (partner→ZACN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.217	+2.674	.001	.006	3	3
CESC	IGBP1P5 →	+0.041	+6.144	<.001	.001	3	2
COAD	ATP5PBP4 →	+0.058	+4.824	<.001	.002	3	2
COAD	SURF6P1 →	+0.167	+3.546	<.001	.004	3	2
BRCA	MIR139 →	+0.391	+7.731	<.001	.009	3	2
CESC	SEPTIN14P1 →	+0.059	+5.539	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 869 associations by consensus.

Exploration

ZACN survival (RNA) · tumor vs normal (RNA) · all ZACN data types