Across TCGA cell cohorts, ZACN mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZACN-associated genes across cancer lineages are GSG1L2, OR3A1, and C6. Each is linked with ZACN in more than 1 cancer types. Because this analysis shows association rather than direction, both ZACN-to-partner and partner-to-ZACN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZACN→partner) and Y-score (partner→ZACN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR3A1 →	+0.732	+4.544	<.001	.003	3	1
BLOOD_Leukemia	C6 →	+0.201	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

ZACN survival (RNA) · tumor vs normal (RNA) · all ZACN data types