YY1AP1

Across TCGA patient cohorts, YY1AP1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YY1AP1-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and mTOR_pS2448. Each is linked with YY1AP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both YY1AP1-to-partner and partner-to-YY1AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by YY1AP1-low versus YY1AP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YY1AP1→partner) and Y-score (partner→YY1AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.739	+2.815	<.001	.036	3	4
UCEC	FoxM1 →	+0.231	+2.392	.011	<.001	3	3
UCEC	mTOR_pS2448 →	-0.125	-1.662	.017	.011	3	3
UCEC	RBM15 →	+0.248	+3.183	.027	.009	3	3
UCEC	C-Raf →	+0.185	+2.321	<.001	.005	3	3
BLCA	GATA3 →	+0.766	+3.169	.004	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by YY1AP1 expression — COAD

Explore this box plot interactively →