YY1AP1

Across TCGA pan-cancer cohorts, YY1AP1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated YY1AP1 data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher YY1AP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YY1AP1 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

ACC, KICH, and KIRP are the cancer types where YY1AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.126	0.740	<.001	116	view →
KICH	DFS	Quartile	II,III,IV	0.347	0.958	<.001	85	view →
KIRP	DFS	Median	III,IV	0.134	0.667	<.001	59	view →
LIHC	OS	Quartile	All	0.682	0.858	<.001	32	view →
UVM	DFS	Median	All	0.695	0.418	.021	32	view →
UCS	DFS	Tertile	IV	0.996	0.361	.024	30	view →
COAD	DFS	Tertile	All	0.750	0.844	.020	16	view →
GBM	DFS	Median	All	0.378	0.206	.007	15	view →
ESCA	DFS	Tertile	III,IV	0.267	0.527	.006	15	view →
LUSC	OS	Median	III,IV	0.598	0.763	.013	14	view →
UCEC	DFS	Median	All	0.563	0.702	.015	14	view →
BRCA	OS	Median	IV	0.738	0.364	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

YY1AP1–ACC (DFS)

Open the ACC breakdown →