YY1

Across TCGA pan-cancer cohorts, YY1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated YY1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher YY1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated YY1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where YY1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	1.000	0.550	<.001	64	view →
HNSC	DFS	Median	All	0.291	1.000	.001	29	view →
LUAD	DFS	Median	III,IV	0.336	0.649	.006	10	view →
CCRCC	DFS	Median	III,IV	0.684	0.461	.028	6	view →
UCEC	DFS	Median	II,III,IV	0.531	0.866	.026	4	view →
PDAC	DFS	Median	III,IV	0.247	0.457	.017	2	view →
GBM	OS	Median	All	0.455	0.305	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

YY1–LSCC (OS)

Open the LSCC breakdown →