YY1

Across TCGA pan-cancer cohorts, YY1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of YY1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where YY1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types YY1 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where YY1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YY1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.563	<.001	12	view →
LUAD	Male	All	+0.330	<.001	9	view →
LSCC	Male	II,III,IV	+0.461	<.001	8	view →
HNSC	All	IV	+0.329	<.001	8	view →
PDAC	Female	All	−0.287	<.001	7	view →
CCRCC	All	II,III,IV	−0.112	.028	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

YY1–COAD

Open the COAD breakdown →