YWHAZ

Across TCGA patient cohorts, YWHAZ mutation is significantly associated with the RNA expression of many other genes, with 2,538 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAZ-associated genes across cancer lineages are RNA5SP242, ZP3P2, and MIR7976. Each is linked with YWHAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAZ-to-partner and partner-to-YWHAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP242 grouped by YWHAZ-low versus YWHAZ-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAZ→partner) and Y-score (partner→YWHAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP242 →	+0.395	+3.376	.004	.007	3	2
CESC	ZP3P2 →	+0.028	+3.839	<.001	.004	3	2
UCEC	MIR7976 →	+0.471	+2.579	<.001	.001	3	2
UCEC	SNORD114-18 →	+0.357	+2.599	.001	.006	3	2
UCEC	RNU6-918P →	+0.359	+2.720	<.001	.004	3	2
UCEC	RNA5SP113 →	+0.353	+3.003	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,538 associations by consensus.

RNA5SP242 by YWHAZ expression — CESC

Explore this box plot interactively →