YWHAEP3

Across TCGA pan-cancer cohorts, YWHAEP3 RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated YWHAEP3 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher YWHAEP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated YWHAEP3 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

LUSC, SKCM, and BLCA are the cancer types where YWHAEP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.105	0.761	<.001	90	view →
SKCM	OS	Tertile	All	0.390	0.788	.026	18	view →
BLCA	OS	Tertile	IV	0.266	0.601	.031	9	view →
STAD	OS	Tertile	II,III,IV	0.816	0.631	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

YWHAEP3–LUSC (DFS)

Open the LUSC breakdown →