YWHAE

Across TCGA pan-cancer cohorts, YWHAE Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated YWHAE data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher YWHAE Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated YWHAE expression acts as an unfavorable survival marker.

OV, STAD, and LGG are the cancer types where YWHAE Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.097	0.542	<.001	48	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
LGG	DFS	Median	All	0.156	0.753	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

YWHAE–OV (DFS)

Open the OV breakdown →