YWHAE

Across TCGA pan-cancer cohorts, YWHAE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated YWHAE data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher YWHAE mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated YWHAE expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where YWHAE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.683	0.213	.011	23	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	22	view →
LSCC	OS	Quartile	All	0.862	0.608	.018	7	view →
LUAD	OS	Tertile	All	0.669	0.906	.035	4	view →
GBM	DFS	Tertile	All	0.198	0.457	.021	4	view →
HNSC	DFS	Quartile	III,IV	0.535	0.978	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

YWHAE–PDAC (DFS)

Open the PDAC breakdown →