YWHAE

Across TCGA pan-cancer cohorts, YWHAE mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of YWHAE’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where YWHAE mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types YWHAE is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

PDAC, LUAD, and CCRCC are the cancer types where YWHAE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YWHAE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.504	<.001	10	view →
LUAD	Female	III,IV	−0.278	<.001	9	view →
CCRCC	Female	All	+0.188	<.001	9	view →
COAD	Male	All	−0.183	<.001	8	view →
LSCC	All	II,III,IV	−0.141	<.001	7	view →
HNSC	All	II,III,IV	−0.096	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

YWHAE–PDAC

Open the PDAC breakdown →