YWHAB

Across TCGA pan-cancer cohorts, YWHAB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated YWHAB data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher YWHAB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated YWHAB expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM, PDAC, and UCEC are the cancer types where YWHAB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.934	0.741	.003	17	view →
PDAC	OS	Tertile	III,IV	0.519	0.222	.033	5	view →
UCEC	OS	Tertile	III,IV	0.539	0.898	.049	4	view →
HNSC	OS	Quartile	II,III,IV	0.974	0.859	.035	3	view →
LUAD	OS	Median	All	0.937	0.674	.023	3	view →
CCRCC	OS	Quartile	III,IV	0.767	1.000	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

YWHAB–GBM (OS)

Open the GBM breakdown →