YWHAB

Across TCGA patient cohorts, YWHAB mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAB-associated genes across cancer lineages are GSK-3_pS9, INPP4B, and MAPK_pT202_Y204. Each is linked with YWHAB in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAB-to-partner and partner-to-YWHAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by YWHAB-low versus YWHAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAB→partner) and Y-score (partner→YWHAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.534	-2.999	.006	.035	3	1
UCEC	INPP4B →	-0.368	-3.169	.018	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.491	-2.459	.030	.020	3	1
UCEC	N-Cadherin →	+0.239	+3.169	.019	.018	3	1
UCEC	p62 Lck ligand →	+0.522	+3.179	<.001	.010	3	1
UCEC	PDCD4 →	-0.768	-2.459	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

GSK-3_pS9 by YWHAB expression — UCEC

Explore this box plot interactively →