YWHAB

Across TCGA cell cohorts, YWHAB mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YWHAB-associated genes across cancer lineages are CHRNA2, UNC79, and MDGA2. Each is linked with YWHAB in more than 1 cancer types. Because this analysis shows association rather than direction, both YWHAB-to-partner and partner-to-YWHAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNA2 grouped by YWHAB-low versus YWHAB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAB→partner) and Y-score (partner→YWHAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHRNA2 →	+0.095	+3.453	<.001	.009	3	1
LARGE_INTESTINE	UNC79 →	+0.134	+3.554	.005	.007	3	1
LARGE_INTESTINE	MDGA2 →	+0.131	+4.176	.001	.001	3	1
LARGE_INTESTINE	SST →	+1.602	+3.453	<.001	.009	3	1
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1
LARGE_INTESTINE	FAM181B →	+0.159	+3.554	.004	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CHRNA2 by YWHAB expression — LARGE_INTESTINE

Explore this box plot interactively →