YTHDF3-AS1

Across TCGA pan-cancer cohorts, YTHDF3-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated YTHDF3-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher YTHDF3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated YTHDF3-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and MESO show a favorable association.

UVM, KIRC, and PAAD are the cancer types where YTHDF3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.433	0.846	<.001	109	view →
KIRC	OS	Tertile	All	0.819	0.906	.005	45	view →
PAAD	OS	Tertile	All	0.540	0.243	.003	34	view →
BLCA	OS	Quartile	IV	0.234	0.769	.004	20	view →
MESO	OS	Median	II,III,IV	0.386	0.206	.015	19	view →
STAD	DFS	Quartile	All	0.859	0.579	.003	18	view →
ESCA	DFS	Quartile	All	0.330	0.576	.007	12	view →
ACC	DFS	Median	III,IV	0.508	0.169	.004	12	view →
LGG	DFS	Median	All	0.682	0.786	.006	9	view →
LIHC	OS	Median	All	0.719	0.839	.014	8	view →
KICH	DFS	Median	IV	0.923	0.317	.038	7	view →
GBM	OS	Quartile	All	0.184	0.489	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

YTHDF3-AS1–UVM (OS)

Open the UVM breakdown →