YTHDF3-AS1

Across TCGA pan-cancer cohorts, YTHDF3-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of YTHDF3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where YTHDF3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types YTHDF3-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where YTHDF3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YTHDF3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.725	<.001	9	view →
THCA	Male	III,IV	−1.055	<.001	9	view →
KIRC	Male	All	−0.856	<.001	8	view →
BLCA	Female	III,IV	+1.078	.002	7	view →
LIHC	Male	II,III,IV	+1.231	<.001	6	view →
STAD	All	All	+0.616	<.001	6	view →
BRCA	All	All	+0.217	.009	4	view →
LUSC	All	All	+0.411	.004	3	view →
KIRP	All	All	−0.564	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

YTHDF3-AS1–KICH

Open the KICH breakdown →