Across TCGA patient cohorts, YTHDF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,726 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible YTHDF2-associated proteins across cancer lineages are RPA2, RCC1, and PUM1. Each is linked with YTHDF2 in more than 5 cancer types. Because this analysis shows association rather than direction, both YTHDF2-to-partner and partner-to-YTHDF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF2→partner) and Y-score (partner→YTHDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPA2 →	+0.310	+0.402	<.001	<.001	3	6
GBM	RCC1 →	+0.309	+0.398	<.001	<.001	3	6
OV	PUM1 →	+0.275	+0.744	<.001	<.001	3	6
GBM	THOC5 →	+0.314	+0.367	<.001	<.001	3	5
GBM	CELF1 →	+0.231	+0.259	<.001	.003	3	5
GBM	DNAJC8 →	+0.377	+0.315	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,726 associations by consensus.

Exploration

YTHDF2 survival (RNA) · tumor vs normal (RNA) · all YTHDF2 data types