Across TCGA patient cohorts, YTHDF2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,846 significant associations in total. GBM shows the largest number of these associations.

The most reproducible YTHDF2-associated genes across cancer lineages are RCC1, AUNIP, and GNL2. Each is linked with YTHDF2 in more than 8 cancer types. Because this analysis shows association rather than direction, both YTHDF2-to-partner and partner-to-YTHDF2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF2→partner) and Y-score (partner→YTHDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCC1 →	+0.694	+0.268	<.001	<.001	3	9
LSCC	AUNIP →	+0.862	+0.298	<.001	<.001	3	8
UCEC	GNL2 →	+0.420	+0.203	<.001	<.001	3	8
OV	SNHG3 →	+0.888	+0.356	<.001	<.001	3	8
HNSC	SNRNP40 →	+0.769	+0.211	.006	<.001	3	8
LSCC	STMN1 →	+0.937	+0.252	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,846 associations by consensus.

Exploration

YTHDF2 survival (RNA) · tumor vs normal (RNA) · all YTHDF2 data types