Across TCGA cell cohorts, YTHDF2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible YTHDF2-associated genes across cancer lineages are NME5, GZMK, and LRRC38. Each is linked with YTHDF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both YTHDF2-to-partner and partner-to-YTHDF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDF2→partner) and Y-score (partner→YTHDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NME5 →	+0.293	+3.379	<.001	.006	3	1
BLOOD_Leukemia	GZMK →	+0.354	+3.622	.005	<.001	3	1
BLOOD_Leukemia	LRRC38 →	+1.086	+3.686	.003	.002	3	1
BLOOD_Leukemia	SPRR1A →	+0.152	+3.464	<.001	.003	3	1
BLOOD_Leukemia	DCLK2 →	+0.820	+3.346	<.001	.008	3	1
BLOOD_Leukemia	SYT9 →	+0.118	+4.027	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

YTHDF2 survival (RNA) · tumor vs normal (RNA) · all YTHDF2 data types