YTHDC2

Across TCGA patient cohorts, YTHDC2 mutation is significantly associated with the RNA expression of many other genes, with 4,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YTHDC2-associated genes across cancer lineages are MRTO4, CGRRF1, and TEDC1. Each is linked with YTHDC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both YTHDC2-to-partner and partner-to-YTHDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRTO4 grouped by YTHDC2-low versus YTHDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YTHDC2→partner) and Y-score (partner→YTHDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRTO4 →	+0.317	+2.747	<.001	<.001	3	4
COAD	CGRRF1 →	+0.383	+2.614	.004	.005	3	4
COAD	TEDC1 →	+0.645	+3.000	<.001	.001	3	3
COAD	FAM72B →	+0.508	+3.000	.001	.001	3	3
COAD	SRA1 →	+0.414	+3.026	<.001	<.001	2	4
COAD	HSBP1L1 →	+0.535	+3.499	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,578 associations by consensus.

MRTO4 by YTHDC2 expression — UCEC

Explore this box plot interactively →