Across TCGA patient cohorts, YRDC mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YRDC-associated genes across cancer lineages are ECM1P1, RN7SKP290, and CYP4F36P. Each is linked with YRDC in more than 1 cancer types. Because this analysis shows association rather than direction, both YRDC-to-partner and partner-to-YRDC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YRDC→partner) and Y-score (partner→YRDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ECM1P1 →	+0.152	+3.091	<.001	.003	3	1
UCEC	RN7SKP290 →	+0.301	+3.621	.001	.004	3	1
UCEC	CYP4F36P →	+0.379	+3.105	.003	.005	3	1
UCEC	MIR6766 →	+0.516	+3.621	<.001	.004	3	1
HNSC	RNU6-956P →	+0.366	+7.954	<.001	.008	3	1
UCEC	H3P46 →	+0.142	+4.292	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Exploration

YRDC survival (RNA) · tumor vs normal (RNA) · all YRDC data types