YPEL4

Across TCGA patient cohorts, YPEL4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YPEL4-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and mTOR_pS2448. Each is linked with YPEL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both YPEL4-to-partner and partner-to-YPEL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by YPEL4-low versus YPEL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YPEL4→partner) and Y-score (partner→YPEL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.158	-3.321	.015	.010	3	1
UCEC	Ku80 →	+0.273	+2.183	.027	.035	3	1
UCEC	mTOR_pS2448 →	-0.182	-2.980	.020	.036	3	1
UCEC	Notch1 →	+0.183	+3.321	.013	.010	3	1
UCEC	p62 Lck ligand →	+0.579	+2.179	<.001	.034	3	1
UCEC	Rab11 →	-0.195	-3.321	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FOXO3a_pS318_S321 by YPEL4 expression — UCEC

Explore this box plot interactively →