YPEL4

Across TCGA pan-cancer cohorts, YPEL4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated YPEL4 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher YPEL4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated YPEL4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, UCS, and KIRP are the cancer types where YPEL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.255	0.159	<.001	103	view →
UCS	OS	Quartile	All	0.679	0.142	.001	98	view →
KIRP	OS	Quartile	III,IV	0.099	0.685	<.001	81	view →
STAD	OS	Tertile	II,III,IV	0.463	0.674	.001	79	view →
ACC	DFS	Median	All	0.247	0.655	<.001	57	view →
LGG	OS	Tertile	All	0.880	0.716	<.001	44	view →
BRCA	OS	Tertile	III,IV	0.922	0.763	<.001	42	view →
HNSC	DFS	Median	IV	0.416	0.219	.003	41	view →
ESCA	OS	Tertile	II,III,IV	0.722	0.395	.005	24	view →
UCEC	DFS	Median	All	0.561	0.729	.006	24	view →
THCA	DFS	Quartile	All	0.927	0.750	.010	18	view →
SCLC	DFS	Tertile	II,III,IV	0.783	0.449	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

YPEL4–SKCM (DFS)

Open the SKCM breakdown →