YPEL3

Across TCGA patient cohorts, YPEL3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YPEL3-associated genes across cancer lineages are MEK1, Rictor_pT1135, and CD49b. Each is linked with YPEL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both YPEL3-to-partner and partner-to-YPEL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by YPEL3-low versus YPEL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YPEL3→partner) and Y-score (partner→YPEL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.536	+3.169	.007	.020	3	1
UCEC	Rictor_pT1135 →	-0.120	-3.169	.033	.020	3	1
UCEC	CD49b →	-0.344	-2.980	.027	.036	3	1
UCEC	PDCD4 →	-0.556	-3.169	.031	.020	2	1
UCEC	EGFR →	-0.276	-3.169	.001	.020	1	1
UCEC	Caspase-8 →	-0.335	-3.169	.015	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by YPEL3 expression — UCEC

Explore this box plot interactively →