YPEL3

Across TCGA pan-cancer cohorts, YPEL3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated YPEL3 data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher YPEL3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated YPEL3 expression acts as an unfavorable survival marker, although some lineages such as MESO and UVM show a favorable association.

MESO, UVM, and HNSC are the cancer types where YPEL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.648	0.348	<.001	102	view →
UVM	DFS	Median	All	0.908	0.576	<.001	90	view →
HNSC	OS	Median	All	0.793	0.709	.001	66	view →
CESC	OS	Tertile	All	0.929	0.816	.002	34	view →
BLCA	OS	Quartile	All	0.606	0.359	.002	30	view →
ACC	OS	Median	II,III,IV	0.949	0.619	.002	30	view →
SKCM	DFS	Quartile	II,III,IV	0.651	0.486	.004	22	view →
LGG	OS	Median	All	0.935	0.853	<.001	22	view →
STAD	DFS	Tertile	II,III,IV	0.569	0.712	.011	20	view →
COAD	DFS	Quartile	All	0.598	0.761	.008	18	view →
CHOL	OS	Tertile	III,IV	1.000	0.331	.036	12	view →
UCEC	OS	Quartile	IV	0.911	0.534	.028	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

YPEL3–MESO (OS)

Open the MESO breakdown →