YME1L1

Across TCGA patient cohorts, YME1L1 mutation is significantly associated with the RNA expression of many other genes, with 3,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YME1L1-associated genes across cancer lineages are RNU6-220P, UFSP2, and EMID1. Each is linked with YME1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both YME1L1-to-partner and partner-to-YME1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-220P grouped by YME1L1-low versus YME1L1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YME1L1→partner) and Y-score (partner→YME1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-220P →	+0.311	+4.606	<.001	.006	3	3
UCEC	UFSP2 →	+0.329	+1.679	.005	.006	3	3
UCEC	EMID1 →	-1.095	-2.193	<.001	<.001	3	3
STAD	OR4P4 →	+0.107	+3.450	.001	.008	3	2
STAD	RNA5SP326 →	+0.357	+4.026	.001	.002	3	2
STAD	RNU6-1056P →	+0.470	+3.705	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,900 associations by consensus.

RNU6-220P by YME1L1 expression — LUSC

Explore this box plot interactively →