YIPF6

Across TCGA pan-cancer cohorts, YIPF6 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated YIPF6 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher YIPF6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated YIPF6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where YIPF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.946	1.000	.037	22	view →
CCRCC	DFS	Quartile	III,IV	0.217	0.706	<.001	17	view →
GBM	DFS	Tertile	All	0.554	0.839	.011	8	view →
LUAD	OS	Quartile	III,IV	0.869	0.560	.039	7	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
UCEC	OS	Median	All	0.982	0.915	.037	2	view →
PDAC	OS	Quartile	III,IV	0.749	0.287	.027	2	view →
LSCC	DFS	Tertile	II,III,IV	0.840	1.000	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

YIPF6–HNSC (OS)

Open the HNSC breakdown →