YIPF6

Across TCGA pan-cancer cohorts, YIPF6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of YIPF6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where YIPF6 RNA is repressed in tumor relative to normal tissue. In most cancer types YIPF6 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where YIPF6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YIPF6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.718	<.001	10	view →
HNSC	All	III,IV	+0.582	<.001	10	view →
LIHC	Male	All	+0.767	<.001	8	view →
LUAD	Male	All	+0.401	<.001	8	view →
BRCA	All	II,III,IV	+0.306	<.001	6	view →
CHOL	All	All	+1.055	.001	5	view →
STAD	All	II,III,IV	+0.452	.012	4	view →
COAD	Male	All	+0.392	.006	4	view →
READ	All	II,III,IV	+0.370	.008	4	view →
LUSC	All	II,III,IV	−0.264	.037	3	view →
PAAD	All	All	+0.694	.031	2	view →
BLCA	Female	All	+0.412	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

YIPF6–THCA

Open the THCA breakdown →