YEATS4

Across TCGA pan-cancer cohorts, YEATS4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated YEATS4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher YEATS4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated YEATS4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and GBM are the cancer types where YEATS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.914	0.708	<.001	36	view →
PDAC	DFS	Median	III,IV	0.496	0.239	.010	24	view →
GBM	OS	Quartile	All	0.778	0.424	.003	8	view →
HNSC	DFS	Median	All	0.698	1.000	.020	7	view →
CCRCC	DFS	Quartile	All	0.840	1.000	.035	4	view →
LUAD	DFS	Tertile	III,IV	0.780	0.357	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

YEATS4–LSCC (OS)

Open the LSCC breakdown →