YEATS4

Across TCGA pan-cancer cohorts, YEATS4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of YEATS4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where YEATS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types YEATS4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, HNSC, and LIHC are the cancer types where YEATS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YEATS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.247	<.001	12	view →
HNSC	Male	IV	+1.098	<.001	12	view →
LIHC	Male	II,III,IV	+1.124	<.001	9	view →
COAD	Female	II,III,IV	+1.032	<.001	8	view →
THCA	All	All	−0.314	<.001	8	view →
STAD	All	All	+0.901	<.001	7	view →
LUSC	Male	All	+0.929	<.001	6	view →
BRCA	All	III,IV	+0.698	<.001	6	view →
ESCA	All	All	+1.133	<.001	5	view →
LUAD	Male	All	+0.818	<.001	5	view →
KICH	All	All	−0.832	<.001	4	view →
CHOL	All	All	+1.932	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

YEATS4–BLCA

Open the BLCA breakdown →